Bulk S-Acetyl L-Glutathione Powder Manufacturer in China
Wholesale 99% pure SAG Powder ( CAS 3054-47-5) with reliable quality control, COA/MSDS documentation, 25kg/drum packaging with OEM service available.
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Bulk S-Acetyl L-Glutathione Powder 99% Pure
| Product Name | S-Acetyl-L-Glutathione |
| Other names | S-GSH, SGSH, Glutathione-S-acetate ,S-Acetylglutathione, S-Acetylglutamylcysteinylglycine,γ-Glutamyl-S-acetylcysteinylglycine, N-(S-acetyl-N-L-γ-glutamyl-L-cysteinyl)- L-γGlu-S-Ac-L-Cys-Gly-OH,SAG,L-γ-glutamyl-S-acetyl-L-cysteinyl-glycine, S-AcGSH,S-A-GSH) |
| CAS Number | 3054-47-5 |
| Molecular Formula | C12H19N3O7S |
| Molecular Weight | 349.36 |
| Specifications | 98% |
| Appearance | White to off-white power |
| Benefits | antioxidant, Detoxification and liver protection, Immune regulation, Skin whitening and anti-aging, Nervous system protection |
| OEM Services | Custom formulation, Private label capsules, Private label tablets, Private label gummies ,powder，contract manufacturing, custom private label & logo service available |
| Bulk Packaging | 25kgs per drum (customize package size service available) |
| Annual supply capacity | 10 ton/ month |
JaYoo Biotech is a leading S-Acetyl L-Glutathione Powder manufacturer in China, supplying high-purity SAG raw materials for global nutraceutical, cosmetic, and functional health product brands. With an annual export volume of over 120 tons, we provide stable bulk supply, strict quality control, COA/MSDS documentation, and 25kg/drum packaging to support distributors, supplement manufacturers, and private label customers.
S-Acetyl L-Glutathione Powder is valued for its improved stability and excellent formulation compatibility compared with standard glutathione. It is widely used in dietary supplements, skin beauty products, anti-aging formulas, antioxidant nutrition, functional foods, and cosmetic ingredient applications.
What is S-Acetyl L-Glutathione?
S-Acetyl L-Glutathione is a stabilized acetylated form of L-glutathione, designed to offer better stability and bioavailability than standard glutathione for supplement, beauty, and antioxidant formulations. It is not commonly extracted directly from botanical or food sources; instead, it is usually produced from glutathione through controlled acetylation to improve its formulation performance. Also known as s acetyl glutathione, SAG, s acetyl l glutathione, s-acetyl-l-glutathione, and S-Acetyl Glutathione, it has the CAS number 3054-47-5, molecular formula C12H19N3O7S, and molecular weight 349.36 g/mol. JaYoo Biotech supplies above 99% pure S-Acetyl L-Glutathione Powder as a white crystalline powder, with good solubility in hot water and slight solubility in cold water, packed in 25kg/drum for bulk orders. As a leading bulk S-Acetyl L-Glutathione supplier in China, JaYoo Biotech provides stable raw material supply, strict quality control, COA/MSDS documentation, and OEM services for finished products such as capsules, tablets, and custom supplement formulas.
S-acetyl Glutathione vs L-glutathione
For premium capsules, tablets, beauty supplements, anti-aging formulas, and high-end antioxidant products, S-Acetyl Glutathione is the better choice because it offers stronger formulation advantages in stability, bioavailability, and premium market positioning. For cost-sensitive products or basic antioxidant formulas, reduced L-glutathione remains a popular and economical option.
| Item | S-Acetyl Glutathione | Reduced L-Glutathione |
|---|---|---|
| Best for | Premium oral supplements, beauty-from-within formulas, anti-aging products, high-end antioxidant formulas | Standard antioxidant supplements, capsules, tablets, functional foods, cosmetic formulas |
| CAS Number | 3054-47-5 | 70-18-8 |
| Other Names | S-Acetyl L-Glutathione, S-Acetyl-L-Glutathione, S-Acetylglutathione, SAG, acetylated glutathione | L-Glutathione reduced, reduced glutathione, GSH, glutathione, glutathione reduced form |
| Note on “S-acetyl NAC” | Not recommended as a synonym. NAC usually means N-acetyl cysteine, a different ingredient | Not applicable |
| Molecular Formula | C12H19N3O7S | C10H17N3O6S |
| Molecular Weight | 349.36 g/mol | 307.32 g/mol |
| Appearance | White to off-white or white crystalline powder | White powder or white crystalline powder |
| Food / Natural Sources | Not commonly extracted from food; usually made by acetylating glutathione | Naturally present in plants, animals, and human cells; dietary sources include fruits, vegetables, meats, and sulfur-rich foods |
| Specification | Commonly ≥98% or ≥99%; JaYoo Biotech supplies above 99% pure SAG powder | Commonly 98%–99% |
| Purity Example | JaYoo COA shows S-Acetyl-L-Glutathione specification ≥98% with actual result 99.4%. | Usually 98%–99% depending on supplier and grade |
| Bioavailability | Higher oral bioavailability potential due to acetyl protection and improved stability; studies report SAG can increase the rate and extent of GSH absorption. (ResearchGate) | Effective but less stable orally; a 6-month RCT found oral GSH at 250 mg/day and 1,000 mg/day increased body glutathione stores in adults. (PubMed) |
| Potency / Efficiency | Usually positioned as a premium, more efficient form; may allow lower serving sizes in formulas | Requires higher or longer supplementation in many formulas |
| Typical Supplement Dosage | Common finished-product range: 100–300 mg/day, sometimes 500 mg/day depending on formula positioning | Common finished-product range: 250–1,000 mg/day |
| Half-life | Exact human plasma half-life for SAG varies by formulation and study design; acetylation is used to improve stability before conversion to GSH | GSH has a short biological half-life; one clinical pharmacokinetic paper notes GSH has a half-life of about 10 minutes, making it difficult to maintain high plasma levels. (PMC) |
| Stability | Better stability during storage and digestion; less prone to oxidation than reduced GSH | More sensitive to oxidation, air, heat, and storage conditions |
| Storage | JaYoo MSDS recommends sealed, dry, dark storage at 2–8°C with inert gas protection. | Usually stored cool, dry, protected from light and air |
| Solubility | Soluble in hot water, slightly soluble in cold water; JaYoo MSDS also notes solubility in PBS buffer. | Freely soluble or soluble in water depending on grade and supplier |
| Blood-Brain Barrier | Often marketed as having better cellular and neurological support potential; animal and mechanistic evidence exists, but more human data is needed | Less commonly positioned for blood-brain barrier support |
| Main Benefits | Antioxidant support, cellular protection, beauty-from-within, skin brightening formulas, anti-aging nutrition, liver health support, immune support | Antioxidant support, detoxification support, immune support, liver health, skin beauty formulas |
| Applied Industries | Dietary supplements, nutraceuticals, beauty supplements, anti-aging formulas, cosmetic ingredients, functional health products | Dietary supplements, nutraceuticals, functional foods, cosmetics, research, pharmaceutical intermediates |
| Popularity | Growing fast in premium supplement brands due to higher-value positioning | More widely known, mature, and commonly used in mass-market formulas |
| Pricing Range | Higher price; rough B2B range can be USD 300–1,000+/kg depending on purity, quantity, stock, and documentation | Lower price; online B2B listings often show about USD 50–120/kg for bulk 99% reduced glutathione. (Made in China) |
| Cost Performance | Better for premium formulas where absorption, stability, and marketing differentiation matter | Better for cost-sensitive products and large-volume standard antioxidant formulas |
| Packaging | JaYoo Biotech bulk package: 25kg/drum. | Commonly 1kg/bag, 5kg/carton, 25kg/drum depending on supplier |
| Market Positioning | Premium glutathione alternative, oral alternative to IV glutathione positioning, high-end beauty and anti-aging products | Standard glutathione ingredient with broad market recognition |
| Safety Notes | SAG safety studies support use in foods or dietary supplements, with one 2025 safety assessment reporting NOAEL at 1,500 mg/kg/day in a 13-week study. (ScienceDirect) | Widely used; high doses may cause digestive discomfort such as nausea or diarrhea in some users |
S-acetyl I-glutathione vs Liposomal Glutathione
Both S-Acetyl Glutathione and Liposomal Glutathione are advanced oral glutathione forms developed to improve the poor stability and absorption of regular reduced glutathione. For premium supplement formulations, S-Acetyl Glutathione is often preferred for stability, cellular uptake, and clean-label powder formulation, while Liposomal Glutathione is valued for fast absorption through lipid encapsulation technology. Current research suggests both forms can increase glutathione levels, but direct head-to-head clinical trials comparing S-Acetyl Glutathione and Liposomal Glutathione are still limited.
S-Acetyl Glutathione, also called S-Acetyl L-Glutathione or SAG, is glutathione modified with an acetyl group attached to the sulfur atom. This structure helps protect the molecule from degradation in the digestive tract and supports better cellular penetration. In one single-dose crossover study, S-Acetyl Glutathione showed a higher plasma glutathione Cmax of 1.97 ± 0.68 μmol/L compared with 1.55 ± 0.52 μmol/L for standard glutathione, and a higher AUC0-t of 6.46 ± 2.19 μmol·h/L compared with 4.88 ± 2.01 μmol·h/L for standard glutathione. This makes SAG a strong choice for capsules, tablets, anti-aging formulas, antioxidant supplements, beauty-from-within products, and premium nutraceutical applications.
Liposomal Glutathione uses liposome encapsulation, where glutathione is enclosed in small lipid bubbles to protect it from stomach acid and digestive enzymes. This delivery system helps transport glutathione into the bloodstream and may improve absorption compared with regular glutathione. In a human study, daily oral liposomal glutathione at 500 mg or 1,000 mg per day for one month increased glutathione levels in blood compartments, with plasma GSH reported to increase by 28% after one week. Some reports also suggest liposomal glutathione may achieve 8–12 times higher peak blood levels and 600–2250% greater total absorption than standard forms, although these values are not directly comparable with SAG because study methods differ.
From a formulation and sourcing perspective, S-Acetyl Glutathione Powder is usually more suitable for bulk ingredient supply because it is a defined raw material with clear specifications such as CAS 3054-47-5, C12H19N3O7S, molecular weight 349.36 g/mol, and purity commonly above 98%–99%. JaYoo Biotech supplies high-purity S-Acetyl L-Glutathione Powder with COA/MSDS documentation and 25kg/drum bulk packaging, making it easier for supplement manufacturers to develop capsules, tablets, sachets, and custom OEM formulas.
In short, S-Acetyl Glutathione is better for brands that need a stable, high-purity bulk powder with strong premium positioning, while Liposomal Glutathione is better for liquid or softgel-style products focused on fast absorption technology. Both forms are more advanced than regular reduced glutathione, but for B2B supplement manufacturing, SAG offers stronger advantages in stability, standardized purity, powder handling, and OEM formulation flexibility.
S-Acetyl L-Glutathione COA
JaYoo Biotech’s S-Acetyl Glutathione Powder COA confirms strict quality control for bulk supplement manufacturing, with product name S-Acetyl-L-Glutathione, CAS No. 3054-47-5, molecular formula C12H19N3O7S, molecular weight 349.36, and batch No. SGSH260421. The tested purity is 99.4%, exceeding the standard specification of ≥98%, while related L-Glutathione is only 0.33% against a limit of ≤1.0%. Key safety indicators meet specification, including total heavy metals ≤10 ppm, Pb ≤2 ppm, Hg ≤0.5 ppm, Cd ≤1 ppm, and As ≤3 ppm, with microbiological limits controlled at total plate count ≤1000 cfu/g, yeast and mold ≤100 cfu/g, and E. coli / Salmonella negative. The COA also confirms loss on drying 0.15%, residue on ignition 0.16%, sulphates ≤300 ppm, and chlorides ≤200 ppm. Residual solvent testing is not listed in this sample COA, but JaYoo Biotech can support additional third-party testing by common methods such as HPLC for assay/purity, ICP-MS or AAS for heavy metals, GC for residual solvents, and microbiological testing according to customer requirements. Packed in 25kg/drum, stored sealed in a cool, dry place away from light and heat, JaYoo Biotech’s S-Acetyl Glutathione Powder meets international quality expectations and supports supplement manufacturers and distributors with reliable documentation, safety control, and third-party quality verification.
| Item | Specification | Result |
|---|---|---|
| Product Name | S-Acetyl-L-Glutathione | Conform |
| CAS No. | 3054-47-5 | Conform |
| Molecular Formula | C12H19N3O7S | Conform |
| Molecular Weight | 349.36 | Conform |
| Batch No. | SGSH260421 | Conform |
| Manufacture Date | 2026-04-21 | Conform |
| Test Date | 2028-04-20 | Conform |
| Package Size | 25kg/drum | Conform |
| Appearance | White to off-white powder | Conform |
| Purity / Assay | ≥98% | 99.4% |
| L-Glutathione | ≤1.0% | 0.33% |
| Sulphates | ≤300 ppm | Conform |
| Chlorides | ≤200 ppm | Conform |
| Loss on Drying | ≤0.5% | 0.15% |
| Residue on Ignition | ≤0.2% | 0.16% |
| Total Heavy Metals | ≤10 ppm | Conform |
| Lead / Pb | ≤2 ppm | Conform |
| Mercury / Hg | ≤0.5 ppm | Conform |
| Cadmium / Cd | ≤1 ppm | Conform |
| Arsenic / As | ≤3 ppm | Conform |
| Total Plate Count | ≤1000 cfu/g | Conform |
| E. coli | Negative | Conform |
| Salmonella | Negative | Conform |
| Yeast and Mold | ≤100 cfu/g | Conform |
| Storage | Sealed packaging, stored in a cool, dry place away from light and heat | Conform |
| Conclusion | All inspection items are in conformity with the specifications | Qualified |
S-Acetyl L-Glutathione Manufacturing Process
JaYoo Biotech produces 99% pure S-Acetyl L-Glutathione Powder through a controlled manufacturing process designed for high purity, stable quality, and bulk supplement applications. The process starts with carefully selected raw materials, followed by an enzymatic reaction to prepare the glutathione intermediate under controlled temperature, pH, and reaction conditions. The material then enters the acetylation stage, where the acetyl group is introduced to improve the stability and bioavailability of the final S-Acetyl L-Glutathione ingredient.
After acetylation, the reaction solution is processed through membrane filtration to remove impurities, salts, and low-molecular residues. The filtered material is then further refined by purification, helping ensure high assay, low impurity levels, and consistent product quality. After purification, the material is carefully dried to produce a stable white to off-white crystalline powder with controlled moisture content.
Before release, every batch undergoes sample testing for key quality indicators, including appearance, purity, related substances, loss on drying, residue on ignition, heavy metals, and microbiological safety. JaYoo Biotech’s S-Acetyl L-Glutathione Powder can reach 99% purity, and the COA example shows a tested purity of 99.4%, with total heavy metals controlled at ≤10 ppm, Pb ≤2 ppm, Hg ≤0.5 ppm, Cd ≤1 ppm, As ≤3 ppm, and microbial limits meeting specification.
The qualified material is finally packed as finished S-Acetyl L-Glutathione Powder, typically in 25kg/drum packaging for bulk buyers. With strict in-process control, COA/MSDS documentation, and support for third-party quality testing, JaYoo Biotech ensures its S-Acetyl L-Glutathione Powder meets international quality standards for supplement manufacturers, nutraceutical brands, distributors, and OEM formulation customers.
S-Acetyl L-Glutathione Applications
S-Acetyl L-Glutathione Powder is a premium glutathione ingredient widely used in dietary supplements, beauty-from-within products, anti-aging formulas, and functional nutrition applications. With improved stability, strong antioxidant properties, and better formulation compatibility, it is an ideal raw material for supplement manufacturers, nutraceutical brands, cosmetic ingredient buyers, and OEM finished-product developers.
Dietary Supplements
Beauty and Skin Brightening Products
Anti-Aging and Cellular Health Formulas
Liver Health and Detox Support
Where to buy bulk S-Acetyl L-Glutathione powder?
Looking for a reliable bulk S-Acetyl L-Glutathione powder supplier in China? JaYoo Biotech Co., Ltd. is a leading S-Acetyl L-Glutathione manufacturer and factory, supplying 99% pure S-Acetyl L-Glutathione Powder, also known as SAG, S-Acetyl Glutathione, S-Acetyl-L-Glutathione, glutathione peptide, and CAS 3054-47-5, for global supplement brands, distributors, and OEM manufacturers.
As a professional wholesale S-Acetyl L-Glutathione supplier, JaYoo Biotech offers stable bulk supply, competitive factory price, free sample support, COA/MSDS documentation, third-party testing, and quality certificates such as GMP, Kosher, Halal, and other export documents upon request. Our S-Acetyl L-Glutathione raw material is widely used in glutathione tablets, capsules, beauty supplements, antioxidant formulas, anti-aging products, glutathione patches, and premium oral alternatives positioned around the glutathione IV market.
JaYoo Biotech also provides flexible OEM services for finished products, including S-Acetyl L-Glutathione capsules, tablets, powder blends, private label formulas, and custom supplement packaging. For buyers searching for bulk S-Acetyl L-Glutathione powder, China glutathione factory, wholesale SAG powder, high-quality glutathione supplier, or S-Acetyl L-Glutathione price, JaYoo Biotech is your trusted partner for safe, high-quality, and export-ready ingredients.