Bulk α-Ketoglutaric acid Manufacturer in China
High-purity α-Ketoglutaric acid powders 98%. α-Ketoglutaric acid capsules, tablets, and OEM services for supplement brands, contract manufacturers, and distributors worldwide.
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Bulk α-Ketoglutaric acid Powder 98%
| Product Name | α-Ketoglutaric acid |
| Other names | α-Ketoglutaric acid;2-Ketoglutaric acid |
| CAS | 328-50-7 |
| molecular formula | C5H6O5 |
| Specifications | 98% available |
| Appearance | White to slightly yellow |
| OEM Services | Custom formulation,Pet functional feed，Pet supplement, capsules, tablets, softgels,powder，contract manufacturing, custom logo |
| Bulk Packaging | 25kg/drum, 1kg -25kg per bag |
| Annual supply capacity | 10000 tons/year |
| Benefits | Supports cellular energy production, promotes healthy aging & longevity, aids amino acid synthesis, enhances exercise recovery, supports nitrogen balance & metabolism |
Alpha-Ketoglutarate (AKG) is a natural key intermediate in cellular energy metabolism, commonly used in dietary supplements, sports nutrition, healthy aging products, and functional health formulas. JaYoo Biotech manufactures high-quality bulk alpha-ketoglutarate powder in China for global distributors, supplement manufacturers, and health brands. We provide a reliable supply, competitive wholesale pricing, OEM support, and rigorous quality control.
What is α-Ketoglutaric acid?
Alpha-Ketoglutaric acid (AKG) is a biologically active organic acid naturally found in the body as a key intermediate of the Krebs cycle. It is widely used in dietary supplements, sports nutrition, and healthy aging products for its central role in energy metabolism and amino acid synthesis (CAS No. 328-50-7). This compound, also called 2-oxoglutaric acid, usually comes with 98% or 99% purity by HPLC testing. It appears as a white crystalline powder that dissolves well in water and is easily absorbed. Alpha-ketoglutaric acid is a single, well-defined compound with a fixed molecular formula of C5H6O5 and a molecular weight of 146.10 g/mol. Its structure allows it to participate in transamination reactions, help remove excess ammonia, and support collagen synthesis. Common derivatives include calcium alpha-ketoglutarate (Ca-AKG) and arginine alpha-ketoglutarate (AAKG). Bulk packaging is typically 25kg per drum with double inner PE bags for export stability. JaYoo Biotech is a leading manufacturer of bulk alpha-ketoglutaric acid powder in China, providing high-quality, factory-direct wholesale ingredients to global B2B buyers, along with OEM services for supplement brands.
α-Ketoglutaric acid Specifications
According to the official specification sheet, JaYoo Biotech’s Alpha-Ketoglutaric Acid (2-oxoglutaric acid, CAS No. 328-50-7) is strictly controlled for assay, purity, and safety, with available specifications of 98% and 99% purity by HPLC. The product appears as a white crystalline powder, with ≥98% assay (HPLC method), and is available in standard and customizable specifications for supplement, sports nutrition, and feed applications. Physical parameters include 95% passing the 80-mesh sieve (CP2020), Loss on Drying ≤0.5% (GB5009.3), and Residue on Ignition ≤0.2% (CP2020) to ensure stability and consistency. Heavy metals are strictly limited: Total Heavy Metals ≤10 mg/kg (Colorimetric method), Lead ≤2 mg/kg (GB5009.12), Arsenic ≤2 mg/kg (GB5009.11), Mercury ≤1 mg/kg (GB5009.17), and Cadmium ≤1 mg/kg (GB5009.15). Microbiological safety complies with international supplement and feed standards: Total Plate Count ≤1000 cfu/g (GB4789.2), Total Yeast & Mold ≤100 cfu/g (GB4789.15), E. coli Negative (GB4789.38), and Salmonella Negative (GB4789.4). The product is packed in 25kg fiber drums with double inner PE bags, has a shelf life of 2 years, and is stored in a cool, dry place at room temperature. All batches are manufactured under standardized quality systems with third-party testing available, ensuring compliance with international quality and safety standards. JaYoo Biotech, as a leading bulk Alpha-Ketoglutaric Acid powder manufacturer in China, is committed to delivering high-purity, internationally compliant ingredients to supplement manufacturers and global distributors, prioritizing product safety, traceability, and long-term supply stability.
Test Items | Specification | Test Methods |
Appearance | White crystalline powder | Visual |
Assay | ≥98% (98% / 99% available) | HPLC |
Particle Size | 95% pass 80 mesh | CP2020 |
Loss on Drying | ≤0.5% | GB5009.3 |
Residue on Ignition | ≤0.2% | CP2020 |
Heavy Metals | ≤10 mg/kg | Colorimetric |
Lead | ≤2 mg/kg | GB5009.12 |
Arsenic | ≤2 mg/kg | GB5009.11 |
Mercury | ≤1 mg/kg | GB5009.17 |
Cadmium | ≤1 mg/kg | GB5009.15 |
Total Plate Count | ≤1000 cfu/g | GB4789.2 |
Total Yeast & Mold | ≤100 cfu/g | GB4789.15 |
E. Coli | Negative | GB4789.38 |
Salmonella | Negative | GB4789.4 |
Storage: Sealed package, store in dry conditions at room temperature.
Standard Packaging: 25kg/drum or carton. Shelf Life: 2 Years.
α-Ketoglutaric acid Manufacturing Process
JaYoo Biotech produces Alpha-Ketoglutaric Acid through a controlled microbial fermentation process, ensuring high purity, natural origin, and batch-to-batch consistency. Production begins with non-GMO fermentation strains and qualified carbon sources, cultivated under strictly monitored conditions where temperature, pH, dissolved oxygen, and feeding rate are precisely controlled to maximize AKG yield. After fermentation, the broth is separated through centrifugation and membrane filtration to remove bacterial cells and proteins. The clarified filtrate then undergoes acidification, activated carbon decolorization, and ion-exchange purification to remove inorganic salts and impurities, followed by controlled crystallization to obtain high-purity AKG crystals. The crystals are vacuum-dried at low temperature to preserve product integrity, then milled and sieved through 80 mesh for uniform particle size. Every batch is released only after passing HPLC assay (≥98%), heavy metals, and microbiological testing. The entire process is executed under GMP-aligned quality management with complete batch records, ensuring full traceability from raw materials to finished goods.
Process Flow:
Fermentation → Filtration → Acidification → Decolorization → Ion-Exchange Purification → Crystallization → Vacuum Drying → Milling & Sieving → QC Testing → Packaging
JaYoo Biotech, as a leading bulk Alpha-Ketoglutaric Acid manufacturer in China, is committed to delivering consistent, high-purity ingredients to global B2B buyers, prioritizing process safety, quality transparency, and long-term supply stability.
α-Ketoglutaric acid Applications
Alpha-Ketoglutaric Acid (AKG) is a versatile functional ingredient whose applications span dietary supplements, clinical nutrition, cosmetics, and animal feed, driven by its central role in cellular energy metabolism and nitrogen transport.
Sports Nutrition: As a key intermediate of the Krebs cycle, AKG participates in ATP production and is widely used in pre-workout and performance formulas. It is often combined with arginine (AAKG) to support nitric oxide (NO) production, blood flow, and nutrient delivery to working muscles. By binding excess nitrogen, AKG also helps reduce exercise-induced ammonia accumulation, supporting endurance and post-training recovery.
Healthy Aging & Longevity: AKG levels naturally decline with age. As a co-substrate for dioxygenase enzymes involved in DNA demethylation and protein hydroxylation, AKG has become a prominent ingredient in longevity supplements, with calcium alpha-ketoglutarate (Ca-AKG) being one of the most recognized forms in healthy-aging formulations.
Collagen & Skin Health: AKG serves as a co-substrate for prolyl hydroxylase in collagen synthesis and provides carbon skeletons for proline and hydroxyproline production. It is applied in beauty-from-within supplements and cosmetic formulations targeting skin elasticity and structural protein support.
Clinical & Medical Nutrition: Through transamination and ammonia detoxification via the urea cycle, AKG is used in clinical nutrition products for nitrogen management and in keto acid-based formulations supporting renal nutrition.
Animal Nutrition: In feed applications, AKG supports nitrogen metabolism, promotes growth performance, and helps animals cope with ammonia stress. It is increasingly used in aquaculture and young animal nutrition to support gut development and overall metabolic health.
JaYoo Biotech supplies bulk Alpha-Ketoglutaric Acid and its derivatives (Ca-AKG, AAKG) to supplement brands, functional food manufacturers, and feed producers worldwide, with consistent quality and full technical documentation for every application.
Where to buy bulk α-Ketoglutaric acid powder?
Looking for a trusted bulk manufacturer in China? JaYoo Biotech Co., Ltd. is a top supplier of Alpha-Ketoglutaric Acid powder, providing factory-direct wholesale to global supplement brands, sports nutrition companies, and distributors. As a leading Chinese manufacturer, we offer high-quality AKG with competitive pricing, consistent supply, and customizable specifications (98%, 99% by HPLC).
We supply both bulk Alpha-Ketoglutaric Acid and its main derivatives, including Calcium α-Ketoglutarate (Ca-AKG) and Arginine α-Ketoglutarate (AAKG), tailored for dietary supplements, healthy aging products, clinical nutrition, and animal feed applications. OEM services include AKG capsules, tablets, and custom formulations. All products are produced in GMP-certified facilities, with third-party testing (COA, MSDS, certifications), and Kosher/Halal options available.
Standard export packaging is 25kg/drum with double inner PE bags. Custom bulk packaging, private label AKG products, and OEM branding are available. Benefit from competitive wholesale prices, rapid worldwide delivery, and free samples for qualified buyers.
Contact JaYoo Biotech today for the latest bulk α-Ketoglutaric Acid price, technical documents, and customized OEM solutions.