Bulk L-Histidine Powder Manufacturer in China

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Pet Nutrition Manufacturer with manufacturing facility

Bulk L-Histidine Powder 99%

Product Name	L-Histidine
Other names	L-His，(S)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid， L-2-Amino-3-(4-imidazolyl)propionic acid
CAS Number	71-00-1
Molecular Formula	C6H9N3O2
Molecular Weight	155.15
Specifications	99% purity
Appearance	White crystalline powder,
Benefits	Skin health and hair health; supports growth development, and tissue repair; regulates digestion and metabolism; protects joints; boosts immunity; and protects the nervous system.
OEM Services	Custom formulation,Pet functional feed，Pet supplement, capsules, tablets, softgels,powder，contract manufacturing, custom logo

Jayoo Biotech is a reliable Bulk L-Histidine Powder Manufacturer in China, supplying high-purity L-Histidine powder to pet nutrition manufacturers, animal feed and animal health producers, veterinary premix companies, pharmaceutical manufacturers, and nutrition ingredient distributors worldwide. Manufactured under strict quality control systems, our L-Histidine powder is designed to meet the consistency and safety requirements of pet food formulations, animal nutrition, clinical nutrition, and pharmaceutical applications. With an annual export capacity of 1,000 metric tons, stable production capability, competitive wholesale pricing, and flexible MOQs, Jayoo Biotech provides a dependable bulk L-Histidine supply solution for long-term sourcing and formulation needs.

What is L-Histidine?

L-Histidine is an imidazole-ring–containing amino acid and a semi-essential amino acid for humans, as infants cannot synthesize sufficient amounts and must obtain it from the diet, while adults can produce limited quantities, and it plays critical roles in protein synthesis, hemoglobin and histamine formation, immune regulation, and maintenance of acid–base balance. It is characterized by good water solubility and high bioavailability. Natural food sources of L-Histidine are mainly animal proteins such as chicken breast, salmon, and eggs, with plant-based sources including soybeans and chickpeas. The CAS number of L-Histidine is 71-00-1, and it is also known as (S)-2-Amino-3-(1H-imidazol-4-yl)propionic acid, with a molecular formula of C6H9N3O2 and a molecular weight of 155.15 g/mol. The product is typically supplied at 99 percent purity by HPLC, appearing as a white crystalline powder that is readily soluble in water. L-Histidine is widely used as a feed additive, food nutrition fortifier, and pharmaceutical raw material, with extensive applications in animal feed, medical foods, infant formula, pet nutrition, and animal health products. Jayoo Biotech is a leading bulk L-Histidine powder supplier in China and also provides OEM services for finished dosage forms such as capsules, tablets, and related formulations, with standard packaging of 25 kg per drum.

L-Histidine Specifications

The Certificate of Analysis for L-Histidine powder from Jayoo Biotech confirms consistent pharmaceutical and food grade quality with an assay of 99.0 to 101.0 percent on a dried basis tested by HPLC in accordance with AJI-92 standards, ensuring high purity for supplement, nutrition, and feed applications. Heavy metal control meets strict international limits, with lead less than or equal to 10 ppm, arsenic less than or equal to 1 ppm, iron less than or equal to 10 ppm, and no abnormal inorganic impurities, supporting safe use in dietary supplements and animal health products. Residual solvent risks are minimized through controlled manufacturing, and the product complies with relevant pharmacopeial and food additive requirements, with loss on drying below 0.20 percent and residue on ignition not more than 0.10 percent, demonstrating excellent process control. Microbiological quality is well controlled, with total aerobic count below 1000 cfu per gram and mold and yeast below 100 cfu per gram. Each batch is packed in sealed 25 kg drums, stored under dry conditions at room temperature, and supported by third-party testing documentation, confirming that Jayoo Biotech’s L-Histidine powder meets international quality and safety standards while reflecting the company’s strong commitment to product quality, regulatory compliance, and long-term reliability for supplement manufacturers and distributors worldwide.

Test Item	Specification / Limit	Test Method / Standard
Product	L-Histidine (CAS 71-00-1), Formula C6H9N3O2, F.W. 155.15	COA identification
Standard / Grade	AJI-92	AJI-92 specification
Appearance	White crystals or crystalline powder, odourless	Visual / organoleptic
Assay (on dried basis)	99.0% to 101.0%	HPLC (per COA) / AJI-92
Specific rotation [α]D20	+12.0° to +12.89°	Optical rotation
pH (1% aqueous solution)	7.0 to 8.5	pH meter
Transmittance	≥98.0%	Spectrophotometry
Loss on drying	<0.20%	Gravimetric
Residue on ignition (sulfated)	≤0.10%	Sulfated ash
Chloride (Cl)	≤0.02%	Chemical (titration)
Sulfate (SO4)	≤0.02%	Chemical (turbidimetry)
Ammonium (NH4)	<0.02%	Chemical
Iron (Fe)	≤10 ppm	ICP / AAS
Lead (Pb)	≤10 ppm	ICP-MS / AAS
Arsenic (As)	≤1 ppm	ICP-MS / AAS
Other amino acids	≤0.5%	Chromatography
Total aerobic microbial count	<1000 cfu/g	Microbiological
Mold and yeast count	<100 cfu/g	Microbiological
Packaging	25 kg/drum, sealed	Packing control
Shelf life	2 years	COA
Storage	Sealed package, store dry at room temperature	Storage instruction

L-Histidine Manufacturing Process

Jayoo Biotech’s L-Histidine powder 99% is produced through a controlled biological fermentation process combined with advanced purification and strict quality management, ensuring high purity, consistent quality, and full compliance with international standards and third-party testing requirements.

Strain Culture: High-performance, non-pathogenic microbial strains are carefully selected and cultivated under sterile conditions to ensure stable L-Histidine biosynthesis, genetic consistency, and production safety.
Biological Fermentation: The cultured strains are transferred into fermenters where temperature, pH, oxygen, and nutrient supply are precisely controlled to maximize L-Histidine yield, minimize by-products, and ensure batch-to-batch consistency.
Purification: The fermentation broth undergoes multi-step purification, including filtration, decolorization, ion exchange, and crystallization, to remove microbial residues and impurities and achieve L-Histidine purity of 99%.
Drying: The purified product is dried under controlled conditions to remove residual moisture while maintaining molecular stability and meeting strict loss-on-drying requirements.
Packaging: The finished L-Histidine powder is packed in sealed, food-grade 25 kg drums under hygienic conditions to prevent contamination and moisture absorption.
Final Product: The final L-Histidine powder meets AJI and other international standards, passes third-party quality testing for purity, heavy metals, and microbiological safety, and is suitable for dietary supplements, pet nutrition, and animal health applications.

L-Histidine Applications

L-Histidine is a critical functional amino acid in animal nutrition, widely used to balance feed amino acid profiles, promote growth and development, improve production performance and product quality, enhance stress resistance and immune health, and support specialized nutritional needs in livestock and aquaculture, making it an essential ingredient for efficient, healthy, and sustainable animal production systems.

Nutritional Supplementation and Growth Promotion

L-Histidine is an essential amino acid for animals, especially during early growth stages such as suckling piglets, chicks, and aquatic larvae. As a key amino acid balancer in feed formulations, it helps optimize the amino acid profile of diets, supports efficient protein synthesis, and promotes skeletal development. Supplementation with L-Histidine improves average daily gain and feed conversion ratio while shortening the overall breeding cycle in livestock and aquaculture.

Improvement of Production Performance and Product Quality

In laying hen diets, L-Histidine supplementation can enhance laying rate, increase eggshell thickness and hardness, and reduce egg breakage. In broiler chickens and pigs, it helps optimize muscle amino acid composition, resulting in improved meat tenderness, brighter meat color, and reduced drip loss. In aquaculture feeds, L-Histidine supports larval survival and growth, enhances stress resistance, and improves size uniformity of aquatic products.

Anti-Stress Support and Health Protection

L-Histidine plays an important role in mitigating stress caused by transportation, high temperatures, weaning, and high stocking density. By regulating immune cell activity, it enhances immune function and reduces disease incidence and mortality under stress conditions. In addition, L-Histidine participates in hemoglobin synthesis and supports healthy hematopoiesis, making it particularly suitable for livestock raised in high-altitude or low-oxygen environments, as well as young animals prone to anemia.

Specialized Animal Nutrition and Feed Optimization

L-Histidine is well suited for young animals such as piglets and chicks, high-producing animals including dairy cows and laying hens, and animals during post-illness recovery. As a functional amino acid supplement, it supports nutrient absorption and metabolic efficiency. Proper inclusion of L-Histidine also helps reduce overall feed formulation costs while aligning with sustainable and green livestock farming practices, making it a valuable ingredient for modern animal nutrition programs.

Where to buy bulk L-Histidine powder?

If you are looking to buy bulk L-Histidine powder from a reliable China factory supplier, Jayoo Biotech is your trusted partner. As a leading high-quality L-Histidine supplier in China, we manufacture and supply 99% pure L-Histidine powder with stable quality, competitive wholesale pricing, and consistent global export standards. Our factory-controlled production ensures full traceability, international compliance, and third-party quality verification, making our products ideal for dietary supplement brands, animal nutrition manufacturers, and ingredient distributors. Jayoo Biotech offers flexible bulk and wholesale supply, transparent high-quality L-Histidine prices, and comprehensive OEM services including capsules and tablets. Free samples are available for qualification and formulation testing, helping customers move efficiently from sourcing to production with confidence.