Intrduction
What is Fisetin? It is a natural flavonoid extracted from plants such as sumac and strawberries, widely used in the animal nutrition and health supplement industries.
This guide covers its core properties, verified benefits, and key differences between feed and supplement grades to help you quickly understand its industrial value.
Chapter 1 Basic Physical and Chemical Information
English Name: Fisetin
CAS No.: 528-48-3
Chemical Name: 3,3′,4′,7-Tetrahydroxyflavone
Molecular Formula: C15H10O6
Molecular Weight: 286.24
Appearance: Yellow or yellow-green needle crystalline powder. It decomposes at high temperature with a melting point of 330°C.
Solubility: Practically insoluble in water, freely soluble in ethanol, acetone, DMSO, and acetic acid. Solubility increases in alkaline solutions.
Industrial Specifications: 50% and 98% purity, tested by HPLC.
Storage Requirements: Store in a cool, dry, and dark place with tight sealing, and avoid moisture and high temperatures.
Raw Material Source: Industrial production is mainly extracted from Cotinus coggygria with stable output and low cost. Natural food sources include strawberries, persimmons, apples, onions, grapes, tomatoes, and cucumbers, with strawberries containing the highest fisetin content.
Chapter 2 Core Functional Mechanism
Fisetin is a natural flavonol polyphenol with four phenolic hydroxyl groups, which determines its powerful biological activity.
1. Powerful Antioxidant & Free Radical Scavenging Capacity. It effectively removes excess free radicals from the body, increases the activity of SOD, GSH-Px, and other endogenous antioxidant enzymes, reduces MDA production, and alleviates oxidative damage to liver, intestinal, ovarian, and skin cells.
2. Selective Senolytic Activity. As one of the rare natural ingredients that can clear senescent cells, fisetin eliminates accumulated aging cells without damaging healthy cells. It effectively reduces chronic inflammation, organ aging, and declines in physiological function, making it a mainstream anti-aging ingredient.
3. Broad-Spectrum Anti-Inflammatory Effect. It inhibits the NF-κB inflammatory pathway, down-regulates pro-inflammatory factors such as TNF-α, IL-1, and IL-6, alleviates systemic low-grade chronic inflammation, and improves intestinal, neuroinflammation, and stress inflammation in breeding animals.
4. Metabolic Regulation. It activates the AMPK pathway and inhibits excessive mTOR activation to stabilize blood sugar and lipid levels and protect vascular endothelium. It also inhibits bacterial virulence and biofilm formation.
Chapter 3 Health Benefits of Human Dietary Supplements
1. Anti-aging and Physical Function Improvement. It removes senescent cells, relieves physical fatigue and memory decline in the elderly, improves muscle strength and physical weakness, and helps extend healthy lifespan.
2. Neuroprotection and Memory Enhancement. It can cross the blood-brain barrier, reduce cerebral oxidative stress and neuroinflammation, repair damaged neurons, relieve forgetfulness and cognitive decline, and has potential improvement effects on Alzheimer ’s-related lesions.
3. Cardiovascular Protection. It protects vascular endothelial cells from oxidative damage, reduces oxidized low-density lipoprotein levels, helps regulate blood lipids, relaxes blood vessels, and alleviates chronic vascular damage.
4. Liver Protection. It alleviates hepatocyte damage induced by heavy metals, oxidative stress, and a high-fat diet, increases liver glutathione reserves, and reduces hepatic fat accumulation.
5. Skin Anti-aging and Anti-photoaging. It neutralizes free radicals generated by ultraviolet rays, protects collagen, and reduces fine lines, dullness, and skin redness caused by inflammation.
6. Immune Regulation. It reduces chronic inflammatory levels, stabilizes immune balance, and prevents the decline in immunity caused by long-term low-grade inflammation.
7. Potential Cell Regulation Effect. In vitro and animal experiments have demonstrated that fisetin regulates the PI3K/Akt/mTOR pathway to inhibit abnormal cell proliferation and induce cell apoptosis. It is only for scientific research and cannot replace medical treatment.
Chapter 4 Application in Feed, Aquaculture, and Pet Industry
1. Livestock and Poultry Breeding (Pigs, Chickens, Ducks)
Fisetin provides antioxidant and anti-stress effects during group transfer, high temperatures, and transportation, reducing stress-related mortality and extending the shelf life of fresh meat. For laying hens, it delays ovarian aging in the late laying period, reduces soft-shelled eggs and spotted eggs, and prolongs the peak laying period. It relieves intestinal damage caused by coccidiosis and enteritis, and improves feed digestion and absorption rate. As a natural antibacterial and anti-inflammatory ingredient, it can partially replace antibiotics, reduce drug residues and drug-resistant bacteria, and meet antibiotic-free breeding standards.
2. Aquaculture (Fish, Shrimp, Grouper)
It inhibits the virulence of Aeromonas hydrophila and Vibrio harveyi, destroys bacterial biofilms, and effectively reduces vibriosis-related mortality in aquatic animals, with a protection rate of 45%-50%. It relieves stress caused by sudden changes in water quality and high-density breeding, thereby improving survival rates. It improves fatty liver and hepatobiliary syndrome of aquatic animals, protects liver and gallbladder health, and promotes growth.
3. Pet Feed (Dogs and Cats)
It delays the aging of organs and joints in elderly pets and improves memory loss and limb weakness. It relieves skin inflammation and itching, improves allergic dermatitis, and reduces skin dullness. It repairs intestinal health, reduces chronic enteritis and loose stools, and enhances pet immunity.
Chapter 5 Safety, Absorption, and Precautions
The oral absorption rate of ordinary fisetin is 5%-10% with a plasma half-life of 2-4 hours. A nano-encapsulated formulation can significantly improve bioavailability. Fisetin is mainly metabolized by the liver and excreted with bile without accumulation in the body.
It has high safety with no liver or kidney toxicity in long-term high-dose animal feeding tests. Derived from natural fruits and vegetables, it complies with food- and feed-grade standards with zero residual risk.
High-dose oral intake may cause slight gastrointestinal discomfort, such as bloating and diarrhea, in a small number of people. Empty-stomach intake can increase irritation, so it is recommended to take it with meals.
High-dose supplementation is not recommended for people with poor coagulation function, perioperative patients, pregnant and lactating women, and people taking anticoagulant drugs.
Chapter 6 Main Application Industries
1. Health food and dietary supplements: applied in anti-aging, brain-protecting, and liver-protecting powder and capsule products.
2. Functional feed additives: widely used in antibiotic-free breeding of livestock, aquaculture, and pets.
3. Cosmetics and skin care products: used in anti-oxidation, soothing, and anti-aging essences.
4. Pharmaceutical intermediates and scientific research reference products: mainly 98% high-purity grade.
Chapter 7 Product Specifications, Packaging, Storage, and Export Standards
1. Main Product Specifications
Two mainstream industrial grades are available and all tested by HPLC. 50% Fisetin Powder: cost-effective, widely used in feed additives, aquaculture, livestock, and pet feed. 98% High-purity Fisetin Powder: high activity, specially used for health supplements, cosmetics, and pharmaceutical research.
2. Product Quality Standard
Extracted from natural Cotinus coggygria, the product is a fine yellow to yellow-green powder without caking and a peculiar smell. It has stable activity, uniform color, and no heavy metal residues, fully meeting international food-grade and feed-grade export standards.
3. Export Packaging Specifications
Sample package: 1kg aluminum foil bag for testing and trial order. Regular package: 5kg aluminum foil bag. Bulk export package: 25kg cardboard drum with double waterproof inner bags. Neutral packaging, custom labels, and OEM packaging are all supported.
4. Storage and Transportation Conditions
Seal tightly, store in a cool, dry, and dark environment, and keep away from high temperatures and humidity. Room temperature transportation is available for sea and land shipping without a cold chain required. Shelf life: 24 months.
5. Core Product Advantages for Export
100% natural plant extract, antibiotic-free, zero addition and low residue; stable batch content and color difference; stable antioxidant, anti-inflammatory and anti-aging activity; compliant with global feed and health product access standards. We can provide complete documents including COA, test reports and customs declaration materials to support global export business.
About US： Jayoobio
We are a global manufacturer dedicated to animal nutrition and pet health, providing one-stop, high-value functional feed additive solutions that cover gut health, antioxidant stress, and joint care.
Our portfolio spans three core sectors—livestock gut health, pet joint anti-aging, and aquaculture pigmentation/anti-viral solutions—built on a comprehensive system of plant extracts, natural antioxidants, amino acids, and joint nutrients. Understanding diverse client needs, we offer flexible “One Client, One Strategy” customized formulations and supply complementary functional ingredients to help your products stand out in a competitive market.
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